Insulin lispro protamine is used to reduce high blood sugar levels in patients Insulin lispro protamine is injected under the skin. Humalog Mix KwikPen. HUMALOG é indicado no tratamento de pacientes com diabetes mellitus que necessitam .. médico e leve a embalagem ou bula do medicamento, se possível. 18 abr. B. Humalog Mix 50 Lilly (50% lispro/protamina e 50% lispro). 2,0. .. dicado em bula, o uso combinado de exanatide com.
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Use of injection sites should be rotated so that the same site is not used more than approximately once a month.
Insulin requirements may be reduced in patients with hepatic impairment due to reduced capacity for gluconeogenesis and reduced insulin breakdown; however, in patients with chronic hepatic impairment, an increase in insulin resistance may lead to increased insulin requirements. Insulin requirements and dosage adjustment Insulin requirements may be increased during illness or emotional disturbances.
Method of administration Humalog solution for injection should be given subcutaneously. For the treatment of adults with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis.
Insulin requirements usually fall during the first trimester and increase during the second and third trimesters. Insulin lispro maintains more rapid absorption and elimination when compared to soluble human insulin in patients with hepatic impairment.
Type I glass cartridges, sealed with halobutyl disc seals and plunger heads and secured with aluminium seals. View our Humalog coupons and manufacturer promo offers.
Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness. Clear, colourless, aqueous solution. Before using the KwikPen the user manual included in the package leaflet must be read carefully.
Prescription Drug Search Strengths available for Humalog cartridge: Instructions for use and handling To prevent the possible transmission of disease, each pen must be used by one patient only, even if the needle is changed. Ideal for people with no prescription coverage,or drug is not covered In in vitro tests, including binding to insulin receptor sites and effects on growing cells, insulin lispro behaved in a manner that closely resembled human insulin. It may cause a rash over the whole body, shortness of breath, wheezing, reduction in blood pressure, fast pulse, or sweating.
Humalog may be given shortly before meals. If the patient is comatose, glucagon should be administered intramuscularly or subcutaneously.
Adjustment of dosage may also be necessary if patients undertake increased physical activity or change their usual diet. The pharmacokinetics of insulin lispro reflect a compound that is rapidly absorbed, and achieves peak blood levels 30 to 70 minutes following subcutaneous injection. The number of insulin units is shown in the dose window of the pen regardless of strength and no dose conversion should be done when transferring a patient to a new strength or to a pen with a different dose step.
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Sign Up Log In Cancel. Summary vula safety profile Hypoglycaemia is the most frequent adverse reaction of insulin lispro therapy that a patient with diabetes may suffer. Sustained carbohydrate intake and observation may be necessary because hypoglycaemia may recur after apparent clinical recovery. Severe hypoglycaemia may lead to loss of consciousness, and in extreme cases, death. The duration hymalog action of Humalog is dependent on dose, site of injection, blood supply, temperature, and physical activity.
Humalog 200 Units/ml KwikPen, solution for injection in pre-filled pen
This rapid onset of activity allows a Humalog injection to be given very close to mealtime. Subcutaneous administration should be in the upper arms, thighs, buttocks, or abdomen.
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Combination of Humalog with pioglitazone Cases of cardiac failure have been reported when pioglitazone was used in combination with insulin, especially in patients with risk factors lixpro development of cardiac heart failure. Send coupon directly to your phone. Transferring a patient to another type or brand of insulin Transferring a patient to another type or brand of insulin should be done under strict medical supervision.
Includes Humalog side effects, interactions and indications.
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Insulin lispro did not induce fertility impairment, embryotoxicity or teratogenicity in animal studies. When administered subcutaneously care should be taken when injecting Humalog to ensure that a blood vessel has not lispfo entered. Excipients This medicinal product contains less than 1 mmol sodium 23 mg per dose, i. Humalog KwikPen lis;ro available in two strengths. Overdose can result causing severe hypoglycemia. Active ingredient insulin lispro. Patients must be educated to use the proper injection techniques.
The patient should be given a meal as soon as consciousness is recovered. Any unused product or waste material should be disposed of in accordance with local requirements. The typical activity profile following subcutaneous injection is illustrated below.
Mild hypoglycaemic episodes will respond to oral administration of glucose or other sugar or saccharated products. The following related adverse reactions from clinical trials are listed below as MedDRA preferred term by system organ class and in order of decreasing incidence very common: After injection, the site of injection should not be massaged.
Detailed information on this medicinal product is available on the website of the European Medicines Agency http: Date of revision of the text.